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This basic science text presents the various biological and chemical factors that are involved when chemicals produce harmful effects on biological cells, systems, or whole animals. Dr. Loomis draws upon his experience as a practicing toxicologist and professor of pharmacology to identify and describe the causes and mechanisms in chemical-induced toxicity. He discusses, among other topics, mechanisms in the translocation of chemicals within the biological specimen; biotransformation mechanisms which alter structure, pharmacological action, and toxicity; factors responsible for nonselective as well as selective action of chemicals on various biological specimens; genetic and immunologic mechanisms involved in toxicity; the merits and deficiencies of the use of statistics in evaluating of harmful effects of chemicals.
Essentials of Toxicology is a valuable general source of information on the modern concepts of toxicity from chemicals.
Arena JM. Essentials of Toxicology. JAMA. 1968;204(7):638. doi:10.1001/jama.1968.03140200078042