October 18, 1971

Acetaminophen-Induced Hepatic Necrosis and Renal Failure

Author Affiliations

From the Department of Medicine, University of Southern California School of Medicine, Los Angeles. Dr. Boyer is now with the US Coast Guard, Academy Hospital, New London, Conn.

JAMA. 1971;218(3):440-441. doi:10.1001/jama.1971.03190160088021

A 29-year-old woman ingested 18 gm of acetaminophen with resultant hepatic necrosis and acute renal failure. Since 1966, eighty-six cases of hepatic necrosis secondary to acetaminophen overdose have been described. Acetaminophen overdosage should be considered as one of the causes of acute hepatorenal failure.