A 29-year-old woman ingested 18 gm of acetaminophen with resultant hepatic necrosis and acute renal failure. Since 1966, eighty-six cases of hepatic necrosis secondary to acetaminophen overdose have been described. Acetaminophen overdosage should be considered as one of the causes of acute hepatorenal failure.
Boyer TD, Rouff SL. Acetaminophen-Induced Hepatic Necrosis and Renal Failure. JAMA. 1971;218(3):440-441. doi:10.1001/jama.1971.03190160088021