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November 1, 1971

Therapy for Incubating SyphilisEffectiveness of Gonorrhea Treatment

Author Affiliations

From the Venereal Disease Branch, Center for Disease Control, Atlanta.

JAMA. 1971;218(5):711-713. doi:10.1001/jama.1971.03190180033006

The epidemiologic control of syphilis would be greatly enhanced if gonorrhea therapy were simultaneously curative for incubating syphilis. In a cooperative study, schedules currently recommended by the Public Health Service for gonorrhea treatment in the male and female (aqueous penicillin G procaine, 2.4 and 4.8 million units, respectively) were evaluated in 127 patients exposed to infectious syphilis within a 30-day period. After a three-month clinical and serologic follow-up, these schedules were found to be 100% effective in aborting incubating syphilis. Of a control group of contacts treated with placebo who were exposed to infectious syphilis within 30 days preceding treatment, 30% developed syphilis. Consequently, aqueous penicillin G procaine in the dosage of 2.4 and 4.8 million units is curative therapy for patients with gonorrhea with coexisting incubating syphilis.