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To the Editor.—
After World War II, rabies spread significantly, especially among wild animals, in central Europe. Britain, which had been rabies-free for many decades or centuries, recently has reported the disease in imported dogs (Brit Med J4:185, 1969; 1:584, 1970; 2:742, 1970). Protective rabies immunization continues to hold an important position. For man, vaccines produced from brain tissues are often used, but with a comparatively greater risk of cerebral complications, varying in frequency from 0.005% to 0.6%. With the specific objective of exploring subclinical cerebral injuries in addition to those recognizable, Timm and Wolter (Deutsch Med Wschr95:2108, 1970; 95:2135, 1970) analyzed 125 electroencephalograms from 50 individuals of various age groups (Table) before and during protective rabies immunization, in which Hempt vaccine was used, a vaccine prepared from brain and spinal cord of rabbits infected with virus fixe, inactivated by ether and phenol.
Timm H, Wolter M. EEG Changes Following Rabies Immunization With Hempt Vaccine. JAMA. 1971;218(5):738. doi:10.1001/jama.1971.03190180058019