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July 15, 1968


JAMA. 1968;205(3):23-38. doi:10.1001/jama.1968.03140290005003

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Isotope Injection Attacks Lymphoma  An intralymphatic irradiation technique which combines diagnosis and therapy in a single outpatient procedure is showing "encouraging early clinical results" in patients with malignant lymphoma.Some 200 patients with varying forms of cancer have been treated with the procedure, with or without external irradiation, during the past six years, said Irving M. Ariel, MD. About 80 have had lymphomas.Most extensive use of injections, consisting of iodine-131 in ethiodized oil, has come in four clinical categories:

  • • Treatment of lymphosarcoma after conventional radiation above the diaphragm, providing simultaneous detection and therapy to retroperitoneal and pelvic nodes;

  • • Lymphoma involving the groin area, usually in tandem with external irradiation;

  • • In conjunction with external radiation therapy at certain other difficult sites; and,

  • • As part of general treatment in Stages III and IV of such malignancies.

"Although we have several five year or more 'cures' it