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July 15, 1968

Treatment of Malaria

JAMA. 1968;205(3):186-187. doi:10.1001/jama.1968.03140290078028

To the Editor:—  I read with interest and appreciation the article by Drs. D.C. Martin and John D. Arnold, "Treatment of Acute Falciparum Malaria With Sulfalene and Trimethoprim" (203:476, 1968).You will allow me, I am sure, to correct a misquotation of a few lines attributed to me. The article states that the future of this particular drug combination (sulformetoxine and pyrimethamine) has been clouded somewhat by a report from Bruce-Chwatt that sulformetoxine caused a 1.5% incidence of Stevens-Johnson syndrome during a North African field study.The correct text of the relevant lines1 was:Recent information from Morocco, where this long-acting sulphonamide was administered on a large-scale in repeated and fairly high doses for control of an epidemic of cerebro-spinal meningitis, indicates the need for caution, for there was a disturbing proportion (1.5%) of 'allergo-toxic' skin reactions—most of them mild, but some severe, of the Stevens-Johnson or