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August 19, 1968

Cardiovascular Complications of Imipramine Intoxication

Author Affiliations

From the Department of Pediatrics, the Mount Sinai Hospital and the Mount Sinai School of Medicine, New York.

JAMA. 1968;205(8):588-590. doi:10.1001/jama.1968.03140340058018

A 2 1/2-year-old boy died as a result of cardiovascular complications of imipramine hydrochloride overdosage. Through a direct toxic effect on the myocardium, imipramine lowers myocardial contractility and cardiac output with resultant hypotension. Cardiac arrhythmias are also a constant feature of imipramine toxicity. Since there is no specific antidote to imipramine, treatment of over-dosage with this drug must be directed at its life-threatening circulatory and respiratory manifestations if the patient is to stand any chance for survival.