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January 17, 1972

Tumor to Tumor Metastasis

Author Affiliations


JAMA. 1972;219(3):384. doi:10.1001/jama.1972.03190290070023

To the Editor.—  Metastasis from one neoplasm to an unrelated coexisting neoplasm is a very rare autopsy finding; to our knowledge, fewer than 100 cases have been reported in the English literature. In 40 of these patients the host tumor was another malignant neoplasm and in 56 it was a benign tumor.1 We wish to report two additional cases with tumor to tumor metastasis.

Report of Cases.—Case 1.—  This 74-year-old woman was found in July 1962 to have scirrhous carcinoma of the right breast with metastases to the skin, lymph nodes, lungs, vertebrae, and possibly the liver. She was treated with a combination of diethylstilbestrol and testosterone propionate but her cancer kept growing rapidly, and she died two months later.At autopsy extensive metastatic lesions were found in the skin, lymph nodes, pleurae, lungs, liver, pituitary and adrenal glands, bones and the brain. Metastatic foci were found