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September 8, 1975

Hydatidiform Mole

Author Affiliations

Department of Pathology University of Wisconsin Madison

JAMA. 1975;233(10):1046-1047. doi:10.1001/jama.1975.03260100016004

To the Editor.—  The article by Pour-Reza et al fails to present data that substantiate their conclusion that hypoproteinemia favors the occurrence of hydatidiform mole. The documentation of hypoproteinemia concurrent with hydatidiform mole is not sufficient evidence of a causal relationship, nor is it sufficient evidence of premorbid hypoproteinemia.Ambulatory clinic patients and hospitalized preoperative patients are mismatched with respect to the significant postural changes in plasma water concentration. An increase of as much as 17% in total serum protein concentration may be observed as a subject changes from recumbency to the erect posture. This is due to hemoconcentration as plasma water moves into the interstitial space.1(p177)Pour-Reza et al report a mean total serum protein concentration 19.5% greater in the clinic population compared to the hospitalized population. If concentration changes due to recumbency were eliminated, the total protein difference between the groups might be of less statistical or