Halothane is the anesthetic agent of choice for burn patients in the Burn Unit at Brooke General Hospital. It is used repeatedly—an average of four administrations per patient, with a range to 22. From 1964 through 1968, 408 patients received 1,770 halothane anesthetics. Two cases of liver necrosis occurred, one massive; neither is attributable to halothane. The evidence indicates that repeated administrations of halothane in a six-week period involve no additional risk to the patient.
Gronert GA, Schaner PJ, Gunther RC. Multiple Halothane Anesthesia in the Burn Patient. JAMA. 1968;205(12):878-880. doi:10.1001/jama.1968.03140380082024