Procarbazine hydrochloride, an antineoplastic agent, a teratogen, and a carcinogen, was given to a patient with Hodgkin's disease during the first 5 1/2 weeks of her pregnancy, and a normal infant was delivered. Based on past experience with chemotherapeutic agents given to pregnant women with Hodgkin's disease, the authors present a program of management for the pregnant patient with Hodgkin's disease.
Wells JH, Marshall JR, Carbone PP. Procarbazine Therapy for Hodgkin's Disease in Early Pregnancy. JAMA. 1968;205(13):935-937. doi:10.1001/jama.1968.03140390059020