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To the Editor.—
In their report on near fatal reaction to ingestion of the hallucinogenic drug methylenedioxyamphetamine (MDA), Richards and Borgstedt (218:1826, 1971) state that they could find little information upon it. Gordon Alles (1901-1963), who first made and developed amphetamine, reported quite fully on structure and action of phenethylamines with discussion of MDA Neuropharmacology: Transactions of the Fourth Conference. (Abramson HA, Macy J Jr [eds]: New York, Foundation Press, 1959, pp 181-268).In this, Alles says that on injection of MDA into small animals it was determined that its toxicity is not significantly different from the lethal dosage of phenethylamine or of amphetamine. He fully described the effects on himself of taking a total divided dose by mouth of 1.4 mg/kg in two hours. These effects included visual and auditory distortions, with a tendency to neck-muscle tension, pupil dilatation, and the peculiar phenomenon of seeing himself hit a
Leake CD. Hallucinogenic Drug Reaction—MDA. JAMA. 1972;219(8):1069. doi:10.1001/jama.1972.03190340073029