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Sept 30, 1968

Bone: Fundamentals of the Physiology of Skeletal Tissue

JAMA. 1968;206(1):137. doi:10.1001/jama.1968.03150010085040

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Surprisingly, some members of the scientific community cling to the concept of bone as a more or less inert support for the body. Others, who understand its role in a variety of intricate physiologic reactions, realize that bone is one of the most dynamic tissues. Research scientists respond to the challenge of complex bone structure and function by a multitude of approaches— biochemistry, crystal dynamics, histochemistry, electron microscopy, radioactive tracers, x-ray diffraction, electron spin resonance, infrared spectroscopy, vital stains, microradiography—which lead to rapid advances.

To produce a coherent treatise which bridges the gap between these various disciplines is indeed difficult. The authors review pertinent literature and accomplish their avowed purpose as they show how each important advance uncovers certain facets, all of which in proper perspective produce a unified concept of bone structure and function. The book contains much information, but more importantly, it presents a panorama of bone as