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October 14, 1968

Cytomegalovirus Complement-Fixation Antibody Levels of Leukemic ChildrenResults of a Longitudinal Study

Author Affiliations

From the departments of pediatrics (Drs. Sullivan and Cangir) and pathology (Dr. Butler), University of Texas M. D. Anderson Hospital and Tumor Institute at Houston; and the Department of Pediatrics, University of Rochester (NY) School of Medicine and Dentistry (Dr. Hanshaw).

JAMA. 1968;206(3):569-574. doi:10.1001/jama.1968.03150030025005

Initial cytomegalovirus complement-fixation antibody titers were positive in two of 16 leukemic children (12%) who had received chemotherapy for less than one month. Longitudinal titer determinations in this group showed nine seroconversions, the median time for seroconversion being two months. Illnesses suggestive of viral infection preceded seroconversion in four children. Fulminating, life-threatening pneumonitis developed in one child, who was treated with floxuridine. Antibody titers of initial sera were positive in 12 of 25 children (48%) receiving chemotherapy more than one month. In this second group of children, fluctuations in established titers showed no correlation with clinical events. Further studies are needed to elucidate the pathogenesis of cytomegalic inclusion disease which may be fatal, in transplant recipients and chemotherapy patients experiencing immunosuppression.