Four patients who had received silicone injections had the following complications: migration, hepatic disease manifested as granulomatous hepatitis (previously undescribed, to our knowledge), hypopigmentation, and death. Silicone should now be considered as a possible cause of hepatic granulomas in an appropriate host.
(JAMA 234:308-309, 1975)
Ellenbogen R, Ellenbogen R, Rubin L. Injectable Fluid Silicone TherapyHuman Morbidity and Mortality. JAMA. 1975;234(3):308–309. doi:10.1001/jama.1975.03260160056016