Cryotherapy, which involves use of profound cold in the region of —190 C, has recently been popularized as a definitive therapeutic tool. Externally malignant processes, untreatable by the usual methods, were subjected to palliative freezing. Studies to determine modes of action were not undertaken. Gratifying results were obtained and further use seemed justified in that decreased pain, reduced number of dressings, and smaller resultant tumor volume were notable advantages.
Beggs JH. Cryotherapy as a Palliative Maneuver. JAMA. 1968;206(7):1570-1572. doi:10.1001/jama.1968.03150070108029