Jaundice developed in a patient who was receiving imipramine hydrochloride. Results of a liver biopsy showed findings of cholestatic jaundice identical to those seen in patients with jaundice occurring secondary to treatment with other phenothiazine derivatives.
Short MH, Burns JM, Harris ME. Cholestatic Jaundice During Imipramine Therapy. JAMA. 1968;206(8):1791-1792. doi:10.1001/jama.1968.03150080071021