Rapid clearing of scaling skin in two common skin diseases, X-linked ichthyosis and ichthyosis vulgaris, follows the use of 40% to 60% aqueous solutions of propylene glycol combined with occlusion. Following clearing, intermittent use of this therapy keeps skin free of scales. The therapy can be extended to other skin disorders involving scale accumulation. There are several possible modes of action of this regimen.
Goldsmith LA, Baden HP. Propylene Glycol With Occlusion for Treatment of Ichthyosis. JAMA. 1972;220(4):579-580. doi:10.1001/jama.1972.03200040091019