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April 24, 1972

Propylene Glycol With Occlusion for Treatment of Ichthyosis

Author Affiliations

From the Department of Dermatology, Harvard Medical School, and the Massachusetts General Hospital, Boston. Dr. Goldsmith is a Carl Herzog fellow of the American Dermatological Association.

JAMA. 1972;220(4):579-580. doi:10.1001/jama.1972.03200040091019

Rapid clearing of scaling skin in two common skin diseases, X-linked ichthyosis and ichthyosis vulgaris, follows the use of 40% to 60% aqueous solutions of propylene glycol combined with occlusion. Following clearing, intermittent use of this therapy keeps skin free of scales. The therapy can be extended to other skin disorders involving scale accumulation. There are several possible modes of action of this regimen.