November 25, 1968


JAMA. 1968;206(9):1897-1914. doi:10.1001/jama.1968.03150090007003

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Bone Marrow Transplant 'Success' Linked To Tissue Matching Tests  A two-year-old New York boy with Wiskott-Aldrich syndrome is surviving without major symptoms nearly two months after bone marrow transplants from his nine-year-old sister.Chimeric peripheral blood cells and a previously absent ability to synthesize isohemagglutinins indicate "the patient's immune system has been replaced by that of the donor."Application of tissue typing techniques—previously used mainly for renal transplants—is the key to continued survival (as of Nov 14) of the boy, University of Wisconsin clinicians believe.In contrast to transplants of other organs, bone marrow infusion carries more than the danger of rejection, said Fritz H. Bach, MD."Immunologically competent cells and their precursors are transplanted, raising the difficulties of graftversus-host reactions."

Clinical Response 'Good' In Three  Clinicians in several nations have attempted marrow transplants for leukemia and massive irradiation over the past