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Article
November 25, 1968

Reversal of Central Anticholinergic Syndrome in Man by Physostigmine

Author Affiliations

From the departments of neurology and anesthesiology, College of Physicians and Surgeons, Columbia University, and the Columbia-Presbyterian Medical Center, New York.

JAMA. 1968;206(9):1963-1965. doi:10.1001/jama.1968.03150090039008
Abstract

Physostigmine salicylate in doses of 1 to 2 mg administered parenterally was found to be an effective antidote to intoxication with centrally active anticholinergic agents. Confusion, agitation, hallucinations, stupor, ataxia, dysarthria, and other symptoms were promptly reversed in 26 consecutive patients in whom toxic reactions developed after receiving scopolamine, atropine, or drugs for Parkinson's disease. Physostigmine deserves a place in therapeutics as an antidote to anticholinergic intoxication.

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