Physostigmine salicylate in doses of 1 to 2 mg administered parenterally was found to be an effective antidote to intoxication with centrally active anticholinergic agents. Confusion, agitation, hallucinations, stupor, ataxia, dysarthria, and other symptoms were promptly reversed in 26 consecutive patients in whom toxic reactions developed after receiving scopolamine, atropine, or drugs for Parkinson's disease. Physostigmine deserves a place in therapeutics as an antidote to anticholinergic intoxication.
Duvoisin RC, Katz R. Reversal of Central Anticholinergic Syndrome in Man by Physostigmine. JAMA. 1968;206(9):1963-1965. doi:10.1001/jama.1968.03150090039008