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November 25, 1968


JAMA. 1968;206(9):1966. doi:10.1001/jama.1968.03150090042009

To William F. Windle, PhD, ScD, whose pioneering research on the physiology of the embryo and newborn has extended our knowledge of one of the major causes of cerebral palsy and mental retardation in children, and has pointed the way to their prevention and therapy.

Through Dr. Windle's most recent investigations, new knowledge has been acquired regarding the relationship between changes in behavior and deterioration of the brain, which sheds new hope and light in providing treatment and rehabilitation for brain-damaged children.

Professor Windle discovered a consistent and precise pattern of brain damage following asphyxiation and resuscitation of the infant at birth. He found that this suffocation is a frequent cause of mental retardation and of cerebral palsy.

He and his colleagues were also the first to correlate this pathology with the clinical symptoms of cerebral palsy, and the first to associate it with the condition known as "kernicterus," in