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December 8, 1975

Chloramphenicol Today

Author Affiliations

Southern Illinois University School of Medicine Springfield

JAMA. 1975;234(10):1016. doi:10.1001/jama.1975.03260230016002

To the Editor.—  I read with interest the commentary by Dr William Kitto (233:325, 1975). I would simply like to insert a reminder that tetracyclines are not appropriate drugs for use in young children, where most of the Hemophilus influenzae disease occurs. This caution is, of course, based on the known potential for tetracyclines to stain the unerupted teeth and, on rare occasions, to lead to the syndrome of pseudotumor cerebri. I would not like to see primary-care physicians resort to general usage of tetracyclines on an outpatient basis in children with such infections, and I don't believe this was Dr Kitto's intent. It would be preferable, if ampicillin resistance is a problem in a given physician's practice, that he instead use combination therapy, with either penicillin G or V and sulfa drugs or erythromycin and sulfa.I would also take issue with his final comment about the relationship between