[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.128.52. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
May 15, 1972

Allergy to Radioisotopes Nonexistent

Author Affiliations

University of Miami Miami, Fla

JAMA. 1972;220(7):1013. doi:10.1001/jama.1972.03200070101024

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

To the Editor.—  If indeed Alker et al have had "Long-Term Experience with Isotope Cisternography," (219:1005,1972), they should be aware that "allergy to isotope" is an unknown entity in nuclear medicine procedures. One hundred microcuries of131I would contain.00000081 mg of iodine (8.1×10-8 mg). Normal cerebrospinal fluid contains 0.2μg/100 ml to 18μg/100 ml. The total volume is 100 to 150 ml. During the performance of radioisotope cisternography, one is then adding three orders of magnitude less than the iodine that normally exists. This, of course, does not eliminate the possibility of iodine hypersensitivity, but to reiterate, there is no documented case of hypersensitivity reaction to administered radioisotope. If one complies with the regulation of administering less than 4 mg of albumin in toto, the incidence of adverse effects from this very useful diagnostic procedure is negligible.The same principles apply to radioisotopic studies of the kidneys. Hypersensitivity

×