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June 5, 1972

Outcome of Pregnancy After Induced OvulationFollow-Up of Pregnancies and Children Born After Clomiphene Therapy

Author Affiliations

From the departments of neonatology (Drs. Hack and Brish), obstetrics and gynecology (Drs. Serr, Insler, and Salomy), and the Institute of Endocrinology (Dr. Lunenfeld), Sheba Medical Center Tel-Hashomer, Tel-Aviv University Medical School; and the Department of Life Sciences Bar-Ilan University (Dr. Lunenfeld), Israel.

JAMA. 1972;220(10):1329-1333. doi:10.1001/jama.1972.03200100043009

Eighty-six women reached at least 20 weeks' pregnancy in 96 instances, after ovulation induced by clomiphene citrate. Although 37 of the women had 44 previous pregnancies, there had been a high pregnancy wastage (70.5%) producing only 13 live infants prior to the successful clomiphene therapy. After clomiphene therapy, pregnancies were normal except for a high incidence of toxemia (16.7%) and a possibly increased incidence of prediabetes. The pregnancies resulted in 88 single and 8 twin births. The total fetal and neonatal loss was 6.7%. The loss of single births (3.1%) included two stillbirth infants of prediabetic mothers. The twin loss of 25% was due to prematurity. The incidence of congenital malformations was within normal limits.