June 12, 1972

Medical News

JAMA. 1972;220(11):1417-1426. doi:10.1001/jama.1972.03200110003002

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Lymphocyte abnormalities vary with histologic types of cancer  The existence of abnormalities in lymphocyte function in cancer patients (particularly those with non-lymphoid neoplasms) has been a matter of some controversy. Now an award-winning study by scientists from the Surgery Branch of the National Cancer Institute has begun to resolve the dispute—as well as shed light on the related question of whether these abnormalities are intrinsic or caused by something in the patient's serum.It appears that if the existence of lymphocyte and/or serum abnormalities in cancer patients may be tumor specific, i.e., a matter of tumor histologic type, and not due to clinical stage of the tumor or other factors. Furthermore, accurate demonstration of the existence of such abnormalities may hinge on the comparison of lymphocyte function in cancer patients with that in healthy individuals of the same age group.The James Ewing Resident Award Lecture (clinical) was presented