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June 12, 1972

Autoanalyzer Glucose Problems

Author Affiliations

Nutley, NJ

JAMA. 1972;220(11):1499. doi:10.1001/jama.1972.03200110077029

To the Editor.—  We have investigated the observations reported by Zileli et al, in a letter which appeared in JAMA (215:1986, 1971). They indicated that a tablet containing 10 mg of oxazepam (Serapax), suspended in 2 ml of water, resulted in a level of glucose greater than 500 mg/100 ml by the autoanalyzer FeCN method and the glucose oxidase method.Our efforts have resulted in a confirmation of the results reported by Zileli with the use of oxazepam (Serax) tablets and capsules suspended in water. However, a pure oxazepam (10 mg/ml) suspension did not give the glucose reaction when tested by the auto-analyzer FeCN procedure,1 the Hoffman modification of the Somogyi procedure,2 the glucose oxidase (glucostat),3 the hexokinase (glucostrate),4 and the SMA 12/60 procedure (neocuproine).5 In the case of oxazepam, it would seem that one of the excipients is interfering with the analysis. Although it