In a controlled human study the biological half-life of tolbutamide was found to be reduced more than twofold in alcoholic patients. We suggest that this effect is the result of stimulation by alcohol of a hepatic microsomal enzyme system in the human liver responsible for the metabolism of tolbutamide. The metabolism of other therapeutic agents could be similarly affected by alcohol, and this might lead to irregularities in response to drug treatment.
Kater RMH, Tobon F, Iber FL. Increased Rate of Tolbutamide Metabolism in Alcoholic Patients. JAMA. 1969;207(2):363–365. doi:10.1001/jama.1969.03150150075025