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June 26, 1972

Ascorbic Acid Depletion During Hemodialysis

Author Affiliations

From the Department of Medicine, Cumberland Hospital, Brooklyn-Cumberland Medical Center, and State University of New York, Downstate Medical Center, Brooklyn.

JAMA. 1972;220(13):1697-1699. doi:10.1001/jama.1972.03200130029006

Sixteen patients receiving long-term hemodialysis therapy demonstrated a decline in leukocyte ascorbic acid concentration of 26% during a single hemodialysis. Eight patients receiving 1 gm of ascorbic acid by mouth showed a 76% rise in leukocyte ascorbic acid concentration in three hours, while control subjects showed a 5% increase. When ascorbic acid was added to dialysate baths of 12 patients, plasma ascorbate levels were elevated by 26% at the end of dialysis, and leukocyte levels rose by 11%. Short-term hemodialysis therapy over five consecutive days produced a continuous decline in plasma and leukocyte ascorbate levels. Ascorbic acid loss from leukocytes and plasma during hemodialysis can be prevented by the addition of the vitamin to dialysate concentrate.