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January 20, 1969

Drug-Induced Diseases

JAMA. 1969;207(3):564. doi:10.1001/jama.1969.03150160076031

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This third volume of an important series contains 28 articles, principally from the United States and the Netherlands, with others from India, Israel, Sweden, Switzerland, and the United Kingdom. The articles are uniformly excellent; they are objectively critical and well-organized, and have extensive, up-to-date bibliographies.

The introductory paper will orient the clinician quickly to the field of adverse drug reactions. Meyler classifies reactions into ten categories, such as dose-related toxicity, hypersensitivity, and predisposing inborn errors of metabolism, and illustrates the various categories with brief and clear examples. The thorough review of digitalis toxicity is pertinent in this era in which more patients suffer from overdigitalization than from underdigitalization. Six articles consider the relationship of oral contraceptives to venous and arterial thrombosis, hepatic dysfunction, pseudotumor cerebri, and (!) ovarian fibrosis. It is both clinically and pathogenetically important that methysergide causes endocardial and pulmonary fibrosis as well as retroperitoneal fibrosis,