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January 26, 1976

Immunogenetic Factors in Preeclampsia and EclampsiaErythrocyte, Histocompatibility, and Y-Dependent Antigens

Author Affiliations

From the Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City (Dr Scott), and the departments of obstetrics and gynecology, cell biology, and internal medicine, University of Texas Health Science Center at Dallas (Drs Beer and Stastny).

JAMA. 1976;235(4):402-404. doi:10.1001/jama.1976.03260300028025

Determination of ABO and HL-A antigens and sex ratio of infants born to 46 women with preeclampsia or eclampsia, in comparison with normal controls, disclosed no predominant blood group, HL-A haplotype, or qualitative difference in maternal-fetal incompatibility. These results suggest that a link between immunologic mechanisms and the pathogenesis of toxemia syndromes, if present at all, must be associated with feto-placental tissue-specific antigens.

(JAMA 235:402-404, 1976)