An unusual islet cell adenoma developed in one patient. It caused no symptoms of fasting hypoglycemia, but over a six-year period it had provoked progressively severe attacks of reactive hypoglycemia. Starvation of the patient for 72 hours neither provoked symptoms nor depressed his blood glucose level below 45 mg/100 cc yet he lost consciousness and convulsed from hypoglycemia during three glucose tolerance tests. His tumor produced thousands of microunits of insulin in response to glucose microunits lenge.
Power L. A Glucose-Responsive Insulinoma. JAMA. 1969;207(5):893-896. doi:10.1001/jama.1969.03150180023004