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February 3, 1969

A Glucose-Responsive Insulinoma

Author Affiliations

From the Department of Internal Medicine, Wayne State University School of Medicine and Detroit General Hospital, Detroit.

JAMA. 1969;207(5):893-896. doi:10.1001/jama.1969.03150180023004

An unusual islet cell adenoma developed in one patient. It caused no symptoms of fasting hypoglycemia, but over a six-year period it had provoked progressively severe attacks of reactive hypoglycemia. Starvation of the patient for 72 hours neither provoked symptoms nor depressed his blood glucose level below 45 mg/100 cc yet he lost consciousness and convulsed from hypoglycemia during three glucose tolerance tests. His tumor produced thousands of microunits of insulin in response to glucose microunits lenge.