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February 10, 1969

Coexistent Pernicious Anemia and Idiopathic Hypoparathyroidism in a Woman

Author Affiliations

From the Division of Medicine, St. Luke's Hospital, Cleveland (Drs. Comin and Wieland), and the Department of Medicine, Case Western Reserve University School of Medicine at Cleveland Metropolitan General Hospital (Dr. Hines).

JAMA. 1969;207(6):1147-1149. doi:10.1001/jama.1969.03150190069021

A woman who had onset of pernicious anemia in adulthood subsequently manifested idiopathic hypoparathyroidism. No previous instances of the combination of these two diseases occurring in adults have been reported in detail. Circulating autoantibodies to thyroid microsomes, all three cellular zones of the adrenal cortex and Castle's intrinsic factor (both blocking and precipitating) were demonstrated in the serum of this patient. Periodic assessment of the endocrine status of patients with pernicious anemia should be considered.