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February 16, 1976

Rubella Vaccination-Reply

Author Affiliations

Peter Bent Brigham Hospital Boston

JAMA. 1976;235(7):704. doi:10.1001/jama.1976.03260330014004

In Reply.—  Dr Nitzkin has cited a paper by Sinclair et al in which the sample of patients on whom premarital rubella titers were performed was said to represent "predominantly lower socioeconomic groups"; 46.5% of Cubans, 7.3% of blacks, and 22.7% of others were susceptible. Of Cubans living in the United States prior to the 1964 epidemic, 40% were susceptible. In that study, no attempt was made to indicate that this difference in susceptibility among ethnic groups within the lower socioeconomic class was related to contact with children in and around the home environment. Also, no mention was made of differences in seroconversion during the childbearing years.Our data indicate that primiparas, whether young or old, have a greater risk of having a baby with rubella syndrome. While ethnic and urbanrural differences in rubella susceptibility have been documented in the past, we do not believe that they are relevant to