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February 17, 1969

The Radiobiology of Human Cancer Radiotherapy

Author Affiliations

University of Chicago Chicago

JAMA. 1969;207(7):1357. doi:10.1001/jama.1969.03150200123031

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The author has collected together the recent important contributions radiobiology has made to our knowledge of clinical radiation therapy. A review of the radiobiology of tissue culture systems is followed by a review of in vivo quantitative systems which may apply to the understanding of clinical radiation therapy. The theory of cell killing by x-rays has been developed in a logical fashion. The section on radiosensitivity and human cells reviews the important additions to our knowledge of the radiosensitivity in relation to the cell cycle. The material on the recovery of cells to a single dose of radiation is clearly presented. From that discussion the interplay of two doses of x-rays separated by a time interval is developed. A number of mathematical models are presented in clear and concise fashion to explain the experimental results. The chapter on cell populations expands the information presented in the previous chapter and deals