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To the Editor.—
In extensive foreign travels over the past 20 years I have found succinylsulfathiazole (Sulfasuxidine) a satisfactory prophylactic and very effective in therapy. It has also saved many vacations for traveling companions. Starting four days before departure with 0.5 gm twice a day prophylactically, at the first sign of cramping, nausea, or loose stools increase the dose to 2 to 3 gm daily, restricting the diet to tea, toast, and soup for 24 hours, then gradually increasing the diet. After the acute symptoms subside the prophylactic dosage is continued.Nothing in the discussion mentioned the most probable cause, namely the change of intestinal bacterial flora from unaccustomed foods. Diarrhea is not prevalent while traveling in Northern Europe or Scandinavia where the foods are similar to diets in the United States. It occurs frequently in Southern Europe, Africa, the Caribbean, Central and South America, and Asia. Also, travelers from
Bennett AE. Entero-Vioform. JAMA. 1972;221(7):715. doi:10.1001/jama.1972.03200200061029