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August 21, 1972

Pulmonary Angiothrombotic Granulomatosis in Drug Offenders

Author Affiliations

From the Department of Pathology, Scripps Memorial Hospital, La Jolla, Calif. Dr. Hopkins was formerly Assistant Medical Examiner, Seattle.

JAMA. 1972;221(8):909-911. doi:10.1001/jama.1972.03200210053014

Pulmonary talc granulomatosis is a serious complication of chronic drug abuse related to the parenteral injection of tablet (oral) forms of drugs containing magnesium trisilicate (talc) as filler material. Pulmonary hypertension and fatal cor pulmonale are sequelae. Talcinduced pulmonary granulomas are found in 15%, angiothrombosis in 12%, and histologic evidence of pulmonary hypertension in 8% of a group of known drug offenders. This suggests that the incidence of this lesion is higher than previously reported.