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March 1, 1976

Rates of Cutaneous Reactions to DrugsA Report From the Boston Collaborative Drug Surveillance Program

Author Affiliations

From the Department of Dermatology, Harvard Medical School (Dr Arndt), and the Department of Medicine, Boston University School of Medicine (Dr Jick), Boston.

JAMA. 1976;235(9):918-923. doi:10.1001/jama.1976.03260350022021

Rates of allergic skin reactions to commonly used drugs were estimated from data obtained on 22,227 consecutively monitored medical inpatients. A total of 57 drugs were implicated in skin reactions. Five or more reactions were attributed to each of 22 drugs (or drug groups). Many commonly used drugs did not appear to cause any allergic reactions. The study provides the practicing physician with drug-specific quantitative data that can be used to evaluate the causes of drug-induced rash, itching, or hives.

(JAMA 235:918-922, 1976)