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March 3, 1969

Clinical Diabetes and Its Biochemical Basis

Author Affiliations

American Medical Association Chicago


by W. G. Oakley, D. A. Pyke, and K. W. Taylor, 786 pp, 118 illus, $21, Oxford: Blackwell Scientific Publications, Ltd. (Philadelphia: F. A. Davis Co.), 1968.

JAMA. 1969;207(9):1721. doi:10.1001/jama.1969.03150220137040

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


A combined effort of three principal authors and 11 subsidiary contributors (all members of King's College Hospital and Medical School), the book displays a cohesive unity rarely attained in works of multiple authorship. Reflecting in part the influence of R. D. Lawrence, to whom the book is dedicated, it preserves a conservative approach to practical problems and a skeptical attitude to theoretical propositions. The caution is often excessive. Is pituitary ablation for diabetic retinopathy still to be regarded as an experimental trial? Is the relationship between diabetes and coronary atherosclerosis still "suspected but unproved"? Must we play it cool with diabetic coma, initiating treatment with modest insulin doses to be adjusted at two- to four-hour intervals?

While the first ten chapters are devoted to carbohydrate metabolism, insulin, hormones, and etiology and pathophysiology of diabetes, the bulk of the book deals with clinical facets of diabetes and its complications. Despite some