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March 15, 1976

Dantrolene Deposited in Connective Tissue?

JAMA. 1976;235(11):1108. doi:10.1001/jama.1976.03260370018019

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To the Editor.—  A blind child, severely mentally retarded, with spasticity of the upper and lower extremities due to cerebral palsy also has an opacity of the left cornea. Dantrolene sodium (Dantrium) therapy was initiated on June 16, 1975, 25 mg a day, and was later increased to 50 mg a day, for the spasticity. On reexamination in September 1975, the corneal opacity had turned yellow, the same color as dantrolene sodium. I wonder whether this might be a deposit of the medication in the connective tissue constituting the opacity.