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April 5, 1976

Value of Granulocyte Examination for Bacteria

Author Affiliations

From the departments of medicine and microbiology, West Side Veterans Administration Hospital, and the Abraham Lincoln School of Medicine, University of Illinois Medical Center, Chicago.

JAMA. 1976;235(14):1465-1466. doi:10.1001/jama.1976.03260400031023

Granulocytes from patients with suspected bacteremia and from dogs with staphylococcal bacteremia were examined by light microscopy for the presence of intracellular inclusions that resembled microorganisms. Quantitative blood cultures were done at the same time. Few granulocytic inclusions were observed during a two-hour screening period even when high levels of bacteremia were present. There was no correlation between the number of inclusions and the quantitative blood culture data. The inclusions appear to be artifacts of the staining procedure. This technique has questionable value in the diagnosis of bacteremia and may be misleading.

(JAMA 235:1465-1466, 1976)