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April 5, 1976

Posterior Fossa Tumors With Pathological Laughter

Author Affiliations

From the Department of Neurology, Brook General Hospital, Shooters Hill, London. Dr Achari is now with the Baylor College of Medicine, Houston.

JAMA. 1976;235(14):1469-1471. doi:10.1001/jama.1976.03260400035025

Of two patients with posterior fossa tumor and pathological laughter, one had extrinsic compression of the brain stem; the other had an intrinsic brain-stem lesion. Surgical removal of the epidermoid from the cerebellopontine angle cured the laughter.

The euphoria of multiple sclerosis with paroxysmal laughter and a feeling of joy is to be differentiated from cases in which pathological laughter is a presenting complaint.

(JAMA 235:1469-1471, 1976)