A patient with suspected isoniazid-induced lupus erythematosus had positive reaction for antinuclear antibody, lupus erythematosus cell, gamma and nongamma direct antiglobulin tests. Severe pericarditis with life-threatening pericardial tamponade required emergency pericardiocentesis. Recurrence of the pericardial effusion with tamponade necessitated use of corticosteroids. We suggest use of steroids early in drug-induced lupus erythematosus, if associated with severe pericarditis with any question of pericardial tamponade (even in the face of underlying tuberculosis).
Greenberg JH, Lutcher CL. Drug-Induced Systemic Lupus ErythematosusA Case With Life-Threatening Pericardial Tamponade. JAMA. 1972;222(2):191–193. doi:10.1001/jama.1972.03210020041011