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October 9, 1972

False Glucose Values With Use of Oxazepam

Author Affiliations

Freehold, NJ

JAMA. 1972;222(2):209. doi:10.1001/jama.1972.03210020055015

To the Editor.—  Zileli et al (215:1986, 1971) cautioned against the possibility of falsely high blood glucose values in persons taking oxazepam (Serapax), since a comatose patient who had attempted suicide by ingesting the drug reportedly had a blood glucose level of 1,680 mg/100 ml. Frings (217:1244, 1971) later reported that pure oxazepam gave no in vitro glucose reaction, whereas a 30-mg capsule of oxazepam (Serax) had an apparent glucose content of 50 mg. He concluded that it was the capsule "filler" that reacted, and pointed out that it was highly unlikely that it would affect the blood glucose. Recently, Spiegel and Enthoven (220:1499, 1972) confirmed Zileli's results with capsules and tablets of oxazepam, and corroborated Frings' findings in detecting no glucose-like reaction with the pure drug by using five different methods including glucose oxidase (glucostat) and hexokinase (glucostrate). They suggested the strong possibility of lactose as the "filler," but