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April 21, 1969

Treatment of Gonorrhea

Author Affiliations

White Plains, NY

JAMA. 1969;208(3):535. doi:10.1001/jama.1969.03160030109023

To the Editor:—  Maurer and Schneider (207:946, 1969) report a failure rate of 25% in the treatment of gonorrhea with intramuscularly administered procaine penicillin G. The authors cite a study by Holmes (JAMA 202:461, 1967) in which a high failure rate with this treatment regimen was also noted. However, both these articles deal with cases of gonorrhea acquired in the western Pacific area. The relative resistance to penicillin of gonococcal strains in this area of the world is well known.1 But, in a large series of patients with gonorrhea acquired in the United States, we used the standard treatment of 2.4 million units procaine penicillin G administered intramuscularly. This resulted in an acceptable failure rate of 5.3%.2 Others, also using this dose to treat domestic cases of gonorrhea have had similarly low failure rates.3Physicians treating gonorrhea should not be mislead into believing that penicillin is