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May 3, 1976

Pharmacokinetics in Clinical Practice2. Applications

Author Affiliations

From the Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo.

JAMA. 1976;235(18):1987-1992. doi:10.1001/jama.1976.03260440039020

The pharmacokinetic concepts introduced and defined in a preceding article are now applied to the management of drug therapy for the individual patient. The factors that affect the time course of drug concentrations in plasma produced by repetitive administration include the dosing rate, total clearance, biologic half-life, and systemic availability of the drug. A clinical pharmacokinetics service can monitor drug concentrations in biologic fluids, design individualized drug-dosing regimens, and carry out pharmacokinetic diagnostic work-ups to help determine the reasons for a patient's unusual response to drug therapy.

(JAMA 235:1987-1992, 1976)