Fluorine 18 bone scans are valuable adjuvants in the detection of early metastatic bone disease. In 104 patients with metastatic bone tumors, the scans and roentgenograms correlated in 75% of cases. Where discrepancies occurred, the scans were correct four times as often as the roentgenograms. Osteoblastic lesions were readily defined whereas osteolytic lesions yielded negative scans in four patients with bone metastases. Fluorine 18 scintiphotos also proved more sensitive than serum acid or alkaline phosphatase determinations.
Hopkins GB, Kristensen KAB, Blickenstaff DE. Fluorine 18 Bone Scans in the Detection of Early Metastatic Bone Tumors. JAMA. 1972;222(7):813–814. doi:10.1001/jama.1972.03210070043012