The use of neuromuscular blocking agents as an adjunct to accepted drug therapy in medically irreversible status asthmaticus allows time for the drug therapy to become effective. The accessory muscles of respiration are also relaxed and, therefore, a decrease in oxygen demand by the body occurs. Four cases of medically irreversible status asthmaticus occurred in which pancuronium bromide, a new nondepolarizing neuromuscular blocking agent was used. The advantages of pancuronium bromide over the other nondepolarizing agents are that it does not cause histamine release and has no significant cardiovascular effects.
Levin N, Dillon JB. Status Asthmaticus and Pancuronium Bromide. JAMA. 1972;222(10):1265–1268. doi:10.1001/jama.1972.03210100019004