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The significance of the wide spectrum of histologic findings observed in Hodgkin's disease was an enigma until recently, accounting for its unique and somewhat uncertain position in the scheme of malignant neoplasms. Paragranuloma and sarcoma, the histologic types reported by Jackson and Parker,11 was considered well established as prognostically signficant in a small proportion of cases,12 but clinical staging appeared to provide a more reliable general basis for prognosis and determination of therapy. Investigation in the past decade has focused attention on a defective immunologic system as a result of the demonstrated inability of the host to develop delayed hypersensitivity and delay in homograft rejection.
Recently, we have been able to shed some light on the histologic types through a new approach relating the histologic features to manifestations of the host reaction.12-14 The relationship between histologic findings and the clinical stages of Hodgkin's disease emphasizes the significance
Lukes RJ. Prognosis and Relationship of Histologic Features to Clinical Stage. JAMA. 1972;222(10):1294-1296. doi:10.1001/jama.1972.03210100042013