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June 21, 1976

Ectopic Production of Hormones in Tumors

Author Affiliations

St Agnes Hospital Philadelphia
Hahnemann Medical College and Hospital Philadelphia

JAMA. 1976;235(25):2716-2717. doi:10.1001/jama.1976.03260510010005

To the Editor.—  The subject of ectopic production of hormones in tumors has recently been extensively discussed. Induction of chemotherapy and tumor lysis has been described in association with carcinoid crisis1 or hypoglycemic shock,2 apparently due to the release of humoral factors. We have had the opportunity to observe the unusual occurrence of hypouricemia in oat-cell carcinoma of the lung.

Report of a Case.—  A 60-year-old man was admitted to the urological service at St Agnes Hospital on July 20, 1975, for progressive symptoms of urinary hesitancy. Transurethral resection was performed and yielded benign tissue of prostatic hypertrophy. A hard, 2 × 3-cm, nontender node was felt in the lower-left anterocervical area. A chest x-ray film showed a large mass involving the left lobe, the hilum, and a widely dilated mediastinum. Biopsy of the node showed anaplastic small-cell carcinoma of the oat-cell type. Further metastatic workup was negative.