June 21, 1976

The Pharmacological Basis of Therapeutics

Author Affiliations

American Medical Association Chicago


edited by Louis S. Goodman, Alfred G. Gilman, and George B. Koelle, ed 5; 1,704 pp, with illus, $30, New York, Macmillan, 1975.

JAMA. 1976;235(25):2771. doi:10.1001/jama.1976.03260510059036

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With the assistance of two new associate editors, Alfred G. Gilman and George B. Koelle, the fifth edition retains the excellence set by previous editions of this classic text. To maintain the same overall length, several outmoded areas have been abbreviated or eliminated. There are discussions of many new drugs, as well as promising drugs whose availability in the United States is probable in the near future.

The section on chemotherapy of neoplastic diseases has undergone extensive revision. The introductory section contains a very readable and informative discussion of pharmacokinetics, pharmacodynamics, and an interesting account of the process of development and approval of new drugs. The section on Parkinson disease has been extensively revised, with major emphasis on levodopa. The chapter on neurohumoral transmission and the autonomic nervous system remains the best source of information in this complex and rapidly changing area. The treatment of diuretics is completely up to